CHO Edge System

Integrating genetic tools and data-driven models into cell line development to routinely achieve titers of 7–11 g/L across modalities

Want to speak to a member of the team?

Fill in the form below and we'll be in touch to schedule a short call.

CHO Edge System

Integrating genetic tools and data-driven models into cell line development to routinely achieve titers of 7–11 g/L across modalities

Want to speak to a member of the team?

Fill in the form below and we'll be in touch to schedule a short call.

Why choose CHO Edge?

Reduce your risk of a low titer cell line

Reduce your risk of a low titer cell line

With our CHO Edge System, titers are typically 7-11 g/L or higher for both IgG monoclonal antibodies and more complex bispecific architectures.

Titer Guarantee

5 g/L or it's free

We guarantee high titer cell lines for monoclonal antibodies. If the RCB generated for a mAb is under 5 g/L, the CLD campaign and all commercial use rights are free.

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Benefit from our experience

Our team comprises scientists with combined decades of experience developing cell lines for a wide range of molecules, and helping bring products to market in pharma.

High titers across modalities

Routinely achieve 7-11 g/L clones across biologic modalities using the CHO Edge System.

Figure: Top 12 clones for six different molecules analyzed in a 14 day Ambr® 15 platform process.

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A new approach to biologics production

Asimov’s CHO Edge System incorporates a GS knock-out CHO host, a hyperactive transposase, a library of >1000 characterized genetic elements and advanced computational tools, enabling exploration of vector design space.

Asimov CHO Edge Cycle Diagram

Two ways to work with us

We transfer CHO Edge to your lab

Ship CHO cells icon  We ship you our CHO host and grant software access

Vials of GMP-banked CHO cells with regulatory documentation are shipped to you, and your team is onboarded into our vector design software, Kernel.

Plasmid design interface  You design DNA

Using our parts and computational models, you design a set of expression vectors. We're here to help if needed.

Ship DNA icon  We ship your DNA

We construct, prepare, sequence, QC, and ship plasmid DNA direct to your facility.

DNA transfection into cells  You perform cell line development

You transfect and generate stable cell lines, with technical support from our team.

We perform CLD services in our lab

Cell line selection  You request a stable CHO cell line

Your cell line development campaign begins with you providing us with an amino acid sequence.

DNA design and development interface  We perform CLD and upstream PD with CHO Edge

Cell line and process development is all done at our site using state-of-the-art equipment and industry-leading timelines.

Communication bubbles  We keep you up to date at every stage

We’ll collaborate and share the latest data to ensure project success.

Cell line delivery  We ship you clonal, stable cell lines 

Vials of research cell banks are shipped to your lab, the process is transferred to your site, and documentation for your regulatory filing supplied.

We transfer CHO Edge to your lab

Ship CHO cells icon

We ship you CHO cells and grant software access

Vials of GMP-banked CHO cells with regulatory documentation are shipped to you, and your team is onboarded into our vector design software, Kernel.
   

Plasmid design interface

You design DNA

Using our parts and computational models, you design a set of expression vectors. We're here to help if needed.
   

Ship DNA icon

We ship your DNA

We construct, prepare, sequence, QC, and ship plasmid DNA direct to your facility.
   

DNA transfection into cells

You perform cell line development

You transfect and generate stable cell lines, with technical support from our team.

 

We perform CLD services in our lab

Cell line selection

You request a stable CHO cell line

Your cell line development campaign begins with you providing us with an amino acid sequence.
   

DNA design and development interface

We perform CLD and upstream PD with CHO Edge

Cell line and process development is all done at our site using state-of-the-art equipment and industry-leading timelines.
   

Communication bubbles

We keep you up to date at every stage

We’ll collaborate and share the latest data to ensure project success.
   

Cell line delivery

We ship you clonal, stable cell lines 

Vials of research cell banks are shipped to your lab, the process is transferred to your site, and documentation for your regulatory filing supplied.

 

READY TO CHAT

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